Get Adobe Flash player

fMRI + Cognition | PubMed

Related Articles

Evaluating an acoustically quiet EPI sequence for use in fMRI studies of speech and auditory processing.

Neuroimage. 2010 Oct 1;52(4):1410-9

Authors: Peelle JE, Eason RJ, Schmitter S, Schwarzbauer C, Davis MH

Echoplanar MRI is associated with significant acoustic noise, which can interfere with the presentation of auditory stimuli, create a more challenging listening environment, and increase discomfort felt by participants. Here we investigate a scanning sequence that significantly reduces the amplitude of acoustic noise associated with echoplanar imaging (EPI). This is accomplished using a constant phase encoding gradient and a sinusoidal readout echo train to produce a narrow-band acoustic frequency spectrum, which is adapted to the scanner's frequency response function by choosing an optimum gradient switching frequency. To evaluate the effect of these nonstandard parameters we conducted a speech experiment comparing four different EPI sequences: Quiet, Sparse, Standard, and Matched Standard (using the same readout duration as Quiet). For each sequence participants listened to sentences and signal-correlated noise (SCN), which provides an unintelligible amplitude-matched control condition. We used BOLD sensitivity maps to quantify sensitivity loss caused by the longer EPI readout duration used in the Quiet and Matched Standard EPI sequences. We found that the Quiet sequence provided more robust activation for SCN in primary auditory areas and comparable activation in frontal and temporal regions for Sentences>SCN, but less sentence-related activity in inferotemporal cortex. The increased listening effort associated with the louder Standard sequence relative to the Quiet sequence resulted in increased activation in the left temporal and inferior parietal cortices. Together, these results suggest that the Quiet sequence is suitable, and perhaps preferable, for many auditory studies. However, its applicability depends on the specific brain regions of interest.

PMID: 20483377 [PubMed - in process]


read full article
 
More Articles...
 
Upcoming Events:
Last month December 2014 Next month
M T W T F S S
week 49 1 2 3 4 5 6 7
week 50 8 9 10 11 12 13 14
week 51 15 16 17 18 19 20 21
week 52 22 23 24 25 26 27 28
week 1 29 30 31